Active Studies Seeking Participants

The Amputee Coalition – the leading national organization for people with limb loss – recognizes the value of clinical research in identifying needs, evaluating care, and developing new technologies for people with limb loss.

PDF format requires Acrobat Reader from Adobe. Click here to download the policy that describes the application process through which Amputee Coalition may agree to participate in the recruitment of subjects for research.

If you are a researcher and wish to submit an application for Amputee Coalition’s participation in recruitment as described in the policy, please send an e-mail notification to

Projects Approved for Amputee Coalition Participation

The project(s) on this page are those who have completed all the necessary documentation to assure that the research project’s human subject protocols are approved through a recognized institution’s Institutional Review Board and has provided a statement that there are no commercial conflicts of interest. This listing does not imply endorsement of the Amputee Coalition. Research projects are listed as a service to researchers and the limb loss community. The Amputee Coalition is not responsible for the conduct of the researchers. The sponsoring institution assumes responsibility for researcher conduct.

Ability Prosthetics and Orthotics, Inc. is performing a research study to compare the benefits of two prosthetic ankle-foot devices. The goal is to learn whether a recently developed microprocessor controlled prosthetic ankle-foot device, called the Kinnex, provides an advantage to walking and mobility when compared to a carbon fiber prosthetic ankle-foot devices called the LP Pacifica.  Both prosthetic ankle-foot devices are manufactured by Freedom Innovations, LLC (Irvine, CA).

We are looking for lower limb amputees who meet the following criteria:

  • Have a below knee amputation on one side
  • Between 18 and 99 years old
  • Use prosthesis 8 hours a day or more
  • Have well-fitting prosthesis
  • Body weight below 275 lbs
  • Able to walk unlimited in community (K-level 3)
  • No use of ambulatory aid (no cane or walker)
  • English speaking
  • Non-pregnant

By participating in this study, your walking ability with a prosthesis may get better, stay the same, or get worse. A possible risk is wearing a prosthesis you are not accustomed to could lead to decreased stability and a potential fall. Your participation in the research study may improve access to microprocessor controlled ankle-foot prosthetic devices, because of an increased understanding of the benefit they can provide. You will receive compensation for travel for research visits.

The research study will be performed over a series of three visits, each lasting about three hours. Ability Prosthetics and Orthotics, Inc. will administer the study at the following three locations:

Ability – Hagerstown, MD
246 Eastern Boulevard, Suite 100
Hagerstown, MD 21740

Ability – York, PA
960 South George Street
York, PA 17403

Ability – Charlotte, NC
309 S. Sharon Amity Road, Suite 104
Charlotte, NC 28211

If interested in participating, please contact the Principal Investigator:

Brian Kaluf, BSE, CP
Clinical Outcome and Research Director
Ability Prosthetics & Orthotics, Inc.
10 Enterprise Boulevard, Suite 206
Greenville, SC 29615
Office:  864-605-3476.

Who are we looking for:
Amputees, 18-65 years old, who have a below the knee amputation, who are
currently using a prosthesis. Participants must be at least 1 year post-amputation and able
to walk comfortably with their prosthesis for 30 minutes. Participants must be free of any
serious heart, lung, nervous system disorder, or leg injuries.

What does your participation entail?
Initially, you will be asked to complete a general screening. If you are interested and
eligible for the study, you will be asked to complete the consent process and take part in
20 research visits, taking place at the Providence Veterans Affairs Medical Center. The
purpose of this study is to evaluate the effectiveness of a new type of gait training using
virtual reality.

Participants will be compensated for their time and effort.

For more information call:
Jesse McVaney, Research Assistant
(401) 273-7100 x 6208

The Collaborative on Health Reform and Independent Living, or CHRIL, is a 5-year research project funded by the National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR) to study how health reforms affect working-age adults with disabilities. The CHRIL is currently looking for individuals with disabilities to participate in their research efforts. During the months of April through July, CHRIL staff from the University of Kansas will be interviewing 20-25 adults with disabilities across the US about their experiences using and getting health insurance and/or Medicaid and Medicare. Participants completing an interview will each receive $40.

We are currently recruiting adults 18-63 years of age with disabilities and/or chronic health conditions.
CHRIL hopes YOU can help with this effort! 

If you would like more information about participating in these interviews please visit:
You can also call toll free: 1-855-556-6328 or
Email us:

Thank you!

Researchers at Rice University are interested in your experience with lower-limb prosthesis usage and potential needs for sensory feedback. Team Sixth Sense, an interdisciplinary senior design team consisting of electrical engineers, mechanical engineers, and bioengineers, is conducting a study to better understand the needs of sensory feedback for lower-limb prosthesis users and construct feedback system to provide lower-limb prosthesis users better motion control.

Who can participate?

  • Individuals who are 18 years or older
  • Individuals who have used lower-limb prosthesis

What does participation involve?

  • Completion of an online survey – – less 20 minutes
  • Access the survey now!
  • If you are in Houston and would like to participate in our sensory feedback testing, please contact us for scheduling and details on compensation!

If you would like more information or have any questions, please contact Isabella Yang ( or Fanny Huang ( by email.

This study has been approved by Rice University Institutional Review Board, IRB-FY2017-132 and IRB-FY2017-133.

If so, we are interested to hear from you about your experiences of this and participate in research from the University of Salford – ‘A Content Analysis of factors associated with embodiment of upper limb prostheses’.

We would like to hear from you if your use of a prosthetic limb is due to either amputation or congenital limb absence as long as you have spent some time using a prosthesis.

Please follow this link to a University webpage detailing more information on the research and how to participate or enquire further about the study. Recruitment from 1st June to 31st December 2016 –

Many thanks,

Andrew Hodrien (PhD researcher)

Researchers at Indiana University are interested in your experience with massage therapy treatments. Niki Munk, PhD, LMT and Sarah Shue, MS with the Department of Health Sciences are conducting a study to better understand the experience that individuals with amputations have with massage therapy.

Who can participate?

  • Individuals who are 18 years or older and have at least one amputation
  • Individuals who have OR have never received a massage therapy treatment

What does participation involve?

**In appreciation of participants’ time, each who completes a survey will be entered to win a $20 Amazon gift card!**

If you would like more information or have any questions, please contact Dr. Niki Munk by phone: 317-­‐278-­‐8658 or email:

This study has been approved by Indiana University Institutional Review Board, #1505574988)

The Amputee Coalition is working with Johns Hopkins to improve the lives of persons with limb loss.  We are testing a new program to help people after limb loss. PALS Online is a computer-based, online program that gives information and tips on how to manage pain and improve function following limb loss. Please consider helping us with this project.   Go to our website to hear what other amputees are saying about the program.

Eligibility Criteria:

  • Major Amputation
  • 18 years of age or older
  • Access to the internet using a computer, tablet or phone

If you are eligible and agree to participate, you will:

  • Complete an online assessment about your pain, your function and how you are doing.
  • Complete 8 online lessons at the PALS Online w We estimate it will take 25 minutes to complete each lesson.
  • Again complete an online assessment about your pain, your function and how you are doing after finishing the lessons.
  • Be contacted by study personnel to participate in either a phone call or focus group to give feedback on the program and your experience with PALS Online.

For your participation in the study you will receive;

  • $50 after completing all 8 online lessons,
  • $25 for answering the assessment questions at the end of the lessons.
  • $25 if you participate in the focus group activity
  • You will also help us learn more about how to aid others in their recovery.

If you are interested in learning more and determining if you are eligible for the study, please contact Tricia Kirkhart at  or 410-502-4453 or go to the website and click on Sign Up Now.

Thank you for taking time to learn our project and your commitment to recovery following limb loss.  We look forward to the opportunity to work with you on this project.

Seeking lower limb amputees and individuals with congenital limb differences over the age of 18 to contribute to a questionnaire study conducted by the Orthotics and Prosthetics department of the Baylor College of Medicine.

We are researching the prevalence of common social and psychological challenges faced by lower limb amputees. Completion of the questionnaire will take approximately 30-45 minutes. We will donate $5.00 to the Amputee Coalition for each completed questionnaire.

For more information please contact: Adam Kohn at (856) 287-5023 or

This study is being conducted to determine whether mild electrical stimulation can provide pain relief in people with post-amputation residual limb (stump) or phantom limb pain.

The investigational device and all study related care is provided at no cost.

You may be eligible to participate in this study if:
• You are 18 years of age or older
• You have had at least one lower extremity amputation
• You are experiencing residual limb (stump) and/or phantom limb pain

To learn more about the study and to see if you may qualify, please visit our website at

If so, you may be eligible to participate in a research study to test a new
prosthesis (the DEKA Arm System) controlled by EMG pattern recognition
Volunteers must be 18 years and older with an upper limb amputation at the transradial
or transhumeral level.

This is a two part study
The first part involves in-lab training visits, fittings of socket and prosthetic arm,
questionnaires, testing, audio and video recordings.

The second part involves 12 weeks home use of the DEKA Arm, weekly contact via
phone, and monthly in person visits.

Compensation is provided per visit and travel is reimbursed.

Deborah Dreschnack (813) 558-3918

James A Haley, Veteran’s Hospital13000 Bruce B Downs Blvd, Tampa, FL 33612

We are looking for volunteers over the age of 18 to help us design and test a new survey about the
needs, preferences and abilities of persons with upper limb amputations.

If you are invited to participate, you may be asked to come to the Providence VAMC for an interview,
complete a paper survey or complete a telephone survey. Parking is free, and all volunteers will receive
compensation for their time and effort. Please contact Kate Barnabe at (401) 273-7100 x6272 for more

Invitation for Families to Participate

Researchers at the University of Washington invite parents, who have children between the ages of 6 – 12 years old who use lower extremity prostheses, to participate in a short online survey that will take only 10 minutes to complete.

We’re conducting a study to look at play barriers that might impact children who use lower extremity prostheses’ play behaviors. Play is a very critical occupation of children,, and barriers to play can impact children’s physical and psychosocial growth and development. Positive play experiences and interactions serve to build important cognitive, motor, and social competencies.

The information from this study will ultimately:

Develop an outcome measure that will better identify play barriers for children who use lower extremity prostheses.

Maximize participation in play, across a variety of environments, in children who use lower extremity prostheses.

Inform the development of pediatric lower extremity prostheses that better meet children’s needs for participation in play.

If you are a parent of a child between the ages of 6 – 12 years old, who uses a lower extremity prosthesis, and would like to participate in this survey, please go to the following link:

If you have questions about this survey please contact the Primary Investigator for this study: Cheryl Kerfeld, PT, MS, PhD
(Confidentiality cannot be guaranteed with e-mail)
Thank you for your participation in this survey.

The GRAB lab at Yale University is conducting a research study on investigating how upper limb amputees use their prosthetic devices to complete daily tasks, such as eating, cleaning and washing. The data we gather will allow us to identify strengths and weaknesses in current devices and generate design guidelines that will lead to better prosthetics in the future.

We are currently seeking upper limb amputees to participate in the study. Participants should live within driving distance to New Haven, Connecticut. Residents of New York City and Boston are welcome to apply. Participants must be daily users of their prosthetic device and must have had the device for 6 months or over.

In the first part of the study participants will wear a head-mounted camera in their own homes while completing typical household tasks. In the second part, participants will travel to our laboratory at Yale University, where they will complete similar activities while their movements are recorded by a motion capture system.

Some further details may be found in the following document:

Participants who complete the study will be compensated $320 in addition to travel expenses.

If you are interested in participating, please contact Dr. Adam Spiers for further details and eligibility evaluation.

Phone number: 203-432-4380.

This study is being sponsored by the Telemedicine and Advanced Technology Research Center
(TATRC) US Army Medical Research & Materiel Command (USAMRMC, Ft. Detrick, MD).

The purpose of this study is to evaluate the current state of modern lower extremity prosthetic devices from the perspective of the amputees themselves. The online survey itself takes between 15-20 minutes to complete and is completely voluntary. To be eligible to complete this survey you must:

  • Be 18 years or older
  • Have had a lower limb amputation
  • Currently use a prosthetic device

If you are interested in participating in this survey, please click on the link provided below. Any questions or concerns about the survey can be directed to Jessica Carrignan at

If so, you may qualify for a research study which is investigating whether a type of non-invasive brain stimulation called transcranial Direct Current Stimulation (tDCS) combined with mirror therapy (MT) can change your pain perception.

This research study requires up to 17 visits over 13 weeks to the Spaulding Rehabilitation Network Research Institute in Charlestown, MA.

You may be eligible to participate if you:

  • Are over 18
  • Had a lower limb amputation
  • Have been experiencing chronic pain for at least 3 months

Earn $25 per visit for your participation.

For more information, please contact the Neuromodulation Center
Phone at 617.952.6151

The purpose of this research project is to obtain first-hand accounts of the various coping styles used by adolescents who have experienced limb loss.

All participants will be entered into a $50 Amazon gift card drawing.

The findings of this study will be presented at Wesleyan College’s Scholarship Day in April.

If you are interested in participating in this study, please contact Rebecca Otwell at

*Participants must be at least 18 years of age

We are doing a research study to see if using a Fitbit pedometer and an online peer group changes how much people with a lower limb amputation walk. Participants will receive a Fitbit pedometer and be paid for their time. Participation will last for 2 years.

We are looking for people age 18-89 years who:

  • have a lower-limb amputation involving one or both legs
  • use a prosthesis for at least 6 months
  • walk with their prosthesis at least 4 hours per day

If you are interested in learning more about the study and being screened for eligibility, please call Jan Pecoraro at 206-764-2962. This study is open to Veterans and non-Veterans.

Lead Researcher: Glenn Klute, PhD 1660 S. Columbian Way, Seattle WA 98108. This study is funded by the U. S. Department of Veterans Affairs.


  • Investigators at Nova Southeastern University are studying the benefits of providing amputee specific evidence based-education in a virtual environment and need your help!
  • We are looking for upper and/or lower limb amputees age 18 and older to participate
  • You will be paid for completing surveys, reviewing amputee specific educational modules, and giving us your feedback.

If interested, please contact Sandra Winkler, PhD, OTR/L at 352-222-9106, 954-262-1216, or



Researchers at Altec, Inc ( are developing new ways of controlling prosthetic limbs. We are looking for volunteers with transradial (forearm) amputation to participate in a research study where sensors will be placed on the forearm of your residual limb to record muscle activity. You will perform simple muscle contractions intended to open and close the hand of your residual limb.A prosthesis is not required. Single or multiple 2-3 hour recording sessionsmay be requested.

Research will be conducted onsite at Altec Inc, 23 Strathmore Rd, Natick, MA 01760

Payment will be provided on an hourly basis at $20/hr. Reimbursement is available for ground transportation.

Study Requirements
Male or female
16-65 years old
English speaking
At least 3 months post trans-radial amputation
Otherwise healthy with no neurological disorders
Must ambulate without assistance
Prosthetic limb not required for this phase of the study

If you meet the study requirements and are interested in participating, please contact Dr. Serge Roy at (508) 545-8235 or for more information.

­Nicolas Burden and colleagues at Lancaster University, United Kingdom, are setting out to explore how an individual’s thoughts and feelings about amputation might affect the amount they use a prosthetic limb. They hope that the findings from the study will help to inform services helping people recover after a limb amputation.

The team at Lancaster would like to hear from individuals who have an amputated limb, access to a prosthetic limb and are 16 years of age or above.

If you fit the description above, consider taking part in the brief online study by following
this link;

Or contact Nicolas directly at if you have any questions or to
request a paper copy of the study.

­Researchers at the University of Michigan invite individuals with upper limb loss to participate in an online research survey regarding novel prosthetic technologies. The goals of this study are to:

  • Evaluate general interest in new prosthetic technologies
  • Determine whether demographic factors (like age or level of amputation) affect level of interest in new prosthetic technologies

Your input on these matters is valuable and can help researchers in establishing design criteria for future prostheses.

You are eligible to participate if:

  • You are 18 years of age or older
  • You have an upper limb amputation at the wrist or higher

Participants will receive a gift card for completing the survey.

If you would like to participate, please go to: The survey may also be accessed at:

For more information about this study, please contact Susannah Engdahl at

The principal investigator of this study is Deanna Gates, PhD ( Dr. Gates runs the Rehabilitation Biomechanics Laboratory at the University of Michigan.

We are conducting a research study to develop new prosthesis control technology. This technology uses electrical signals recorded from muscles during muscle contraction to control an upper limb prosthesis.

The outcome of this study may someday allow upper limb amputees to control movements of a prosthesis more naturally and intuitively.


  • As a participant, you will be asked to perform low-level physical activities such as arm reaching, feeding motion, opening/closing your hand, and wrist movement.
  • The research study will be conducted at NC State University in Raleigh, NC.
  • Compensation is $25/hour with a minimum of $50/visit.
  • Participants residing far from our testing center may be eligible for travel and lodging reimbursement.


  • Between the age of 18 and 70
  • At least 1 year post-amputation
  • With amputation between the elbow and wrist
  • Free from cognitive impairment
  • Free from serious illnesses (i.e. stroke, severe heart disease, etc.)
  • Without history of serious illness (cardiac arrest, seizure, etc.)
  • Fluent in English (for consent form and appropriate communication)

For more information, please contact the
program director, Dr. He (Helen) Huang:

Neuromuscular Rehabilitation Engineering Lab
Joint Department of Biomedical Engineering

The purpose of this research study is to evaluate known risk factors of cardiovascular disease (i.e. weight, diet, exercise).

Studies have shown that people who have amputations may have an increased risk of some of these risk factors.

You may benefit from early detection of risk factors of developing cardiovascular disease. However, no benefit can be guaranteed.


  1. Over the age of 18
  2. > 3 months since most recent surgery
  3. No orthopedic injury treated during past year


Orthopedic injury treated during past year (not major limb loss)


Major limb loss resulting from trauma

Time commitment:

  • 2 visits (baseline & 5 yr follow-up)
  • Each visit ~ 90 minutes

Location of Testing:

  • WRNMMC Nutrition Research Laboratory
  • WRNMMC Amputee Care Service

If interested, please contact:

Alison Pruziner
(Principal Investigator)

The Department of Rehabilitation at Walter Reed National Military Medical Center (WRNMMC) is currently recruiting up to 105 individuals with (and without) lower-extremity trauma or amputations to investigate how spine motion affects loads in the low back, and how these motions/loads are related to the current health of the spine and tissues in the low back.

Eligibility: Age = 18-45 years

Unilateral transtibial or transfemoral amputation, or no injuries
No upper-extremity amputation(s) above the wrist Current (or no) low back pain

Time Commitment: a single 2-hour visit

Location: Biomechanics Laboratory, America Building (19), Room B314

Possible Benefits: Results from this study could improve our understanding of why persons with lower-extremity amputation are susceptible to low back pain.

For more information, contact:
Brad Hendershot, PhD
America Building (19), Room B-311

1) Over the age of 18
2) Below-knee amputation on only one leg
3) Over a year since your amputation
4) Able to use your prosthesis, but you have difficulty doing high-level activities, such as running or jumping

Location of Testing
Walter Reed National Military Medical Center

  • Amputee Center
  • Prosthetics and Orthotics Service
  • Military and Advanced Training Center

Time Commitment
One year
First 6 months: 5 clinic visits and 2 prosthetic fittings
Second 6 months: 2 telephone calls to complete questionnaires

Purpose of Study

The purpose of the study is to learn if there are differences between a powered ankle prosthesis and the unpowered prosthesis you currently
wear. We will look at differences in how you walk in both prostheses, if one allows you to use less energy when you walk, and if one allows you to participate in and perform more activities than the other.

There is no guarantee that you will benefit from this study, however other research studies have shown that the use of a powered ankle prosthesis may decrease the stress on your un-amputated leg and may reduce the energy you require to complete daily tasks.

Principle Investigator:
Alison Pruziner

If interested, please contact:
Caitlin Mahon

Researchers at the University of Illinois at Chicago, in collaboration with practitioners at Scheck and Siress Orthotics and Prosthetics, are trying to understand how different socket suspension systems affect how much you use your prosthetic, your balance confidence and your locomotor capabilities.

Your participation would involve filling out short on-line surveys from home. The total time to complete all surveys is 15-20 minutes and you will be compensated for your time.

We are looking for participants that meet the following criteria:

  • Must be at least 18 years of age
  • Must be at least 1 year since amputation
  • Must be using current prosthetic for at least 6 months
  • Must have, or have access to an active email account
  • Must walk without the use of a cane or walker
  • Must answer yes to the following: “I can walk continuously for 6 minutes.”
  • Must not currently use a vacuum assisted socket suspension system

For further information, please contact the primary investigator, Noah Rosenblatt, PhD, at 312-996-2747.

This study is funded by the American Orthotic and Prosthetics Association

A multi-center study is underway utilizing an investigational medical device for people with post-amputation pain. If you are experiencing moderate to severe post-amputation pain not controlled by medication, we invite you to learn more.

Qualifications for study participation include:

  • One amputated lower limb
  • Frequent and recurring amputation pain
  • Willingness to undergo surgery
  • 21 years of age or older

The purpose of this clinical study is to evaluate whether electrical nerve block is a safe and effective treatment for patients with post-amputation pain. You will not be charged for any study related appointments or procedures.

For more information please contact: Neuros Medical, Inc.,,