Active Studies Seeking Participants

The Amputee Coalition – the leading national organization for people with limb loss – recognizes the value of clinical research in identifying needs, evaluating care, and developing new technologies for people with limb loss.

PDF format requires Acrobat Reader from Adobe. Click here to download the policy that describes the application process through which Amputee Coalition may agree to participate in the recruitment of subjects for research.

If you are a researcher and wish to submit an application for Amputee Coalition’s participation in recruitment as described in the policy, please send an e-mail notification to

Projects Approved for Amputee Coalition Participation

The project(s) on this page are those who have completed all the necessary documentation to assure that the research project’s human subject protocols are approved through a recognized institution’s Institutional Review Board and has provided a statement that there are no commercial conflicts of interest. This listing does not imply endorsement of the Amputee Coalition. Research projects are listed as a service to researchers and the limb loss community. The Amputee Coalition is not responsible for the conduct of the researchers. The sponsoring institution assumes responsibility for researcher conduct.

The purpose of this study is to evaluate the current state of modern lower extremity prosthetic devices from the perspective of the amputees themselves. The online survey itself takes between 15-20 minutes to complete and is completely voluntary. To be eligible to complete this survey you must:

  • Be 18 years or older
  • Have had a lower limb amputation
  • Currently use a prosthetic device

If you are interested in participating in this survey, please click on the link provided below. Any questions or concerns about the survey can be directed to Jessica Carrignan at

If so, you may qualify for a research study which is investigating whether a type of non-invasive brain stimulation called transcranial Direct Current Stimulation (tDCS) combined with mirror therapy (MT) can change your pain perception.

This research study requires up to 17 visits over 13 weeks to the Spaulding Rehabilitation Network Research Institute in Charlestown, MA.

You may be eligible to participate if you:

  • Are over 18
  • Had a lower limb amputation
  • Have been experiencing chronic pain for at least 3 months

Earn $25 per visit for your participation.

For more information, please contact the Neuromodulation Center
Phone at 617.952.6151

The purpose of this research project is to obtain first-hand accounts of the various coping styles used by adolescents who have experienced limb loss.

All participants will be entered into a $50 Amazon gift card drawing.

The findings of this study will be presented at Wesleyan College’s Scholarship Day in April.

If you are interested in participating in this study, please contact Rebecca Otwell at

*Participants must be at least 18 years of age

We are doing a research study to see if using a Fitbit pedometer and an online peer group changes how much people with a lower limb amputation walk. Participants will receive a Fitbit pedometer and be paid for their time. Participation will last for 2 years.

We are looking for people age 18-89 years who:

  • have a lower-limb amputation involving one or both legs
  • use a prosthesis for at least 6 months
  • walk with their prosthesis at least 4 hours per day

If you are interested in learning more about the study and being screened for eligibility, please call Jan Pecoraro at 206-764-2962. This study is open to Veterans and non-Veterans.

Lead Researcher: Glenn Klute, PhD 1660 S. Columbian Way, Seattle WA 98108. This study is funded by the U. S. Department of Veterans Affairs.


  • Investigators at Nova Southeastern University are studying the benefits of providing amputee specific evidence based-education in a virtual environment and need your help!
  • We are looking for upper and/or lower limb amputees age 18 and older to participate
  • You will be paid for completing surveys, reviewing amputee specific educational modules, and giving us your feedback.

If interested, please contact Sandra Winkler, PhD, OTR/L at 352-222-9106, 954-262-1216, or



Researchers at Altec, Inc ( are developing new ways of controlling prosthetic limbs. We are looking for volunteers with transradial (forearm) amputation to participate in a research study where sensors will be placed on the forearm of your residual limb to record muscle activity. You will perform simple muscle contractions intended to open and close the hand of your residual limb.A prosthesis is not required. Single or multiple 2-3 hour recording sessionsmay be requested.

Research will be conducted onsite at Altec Inc, 23 Strathmore Rd, Natick, MA 01760

Payment will be provided on an hourly basis at $20/hr. Reimbursement is available for ground transportation.

Study Requirements
Male or female
16-65 years old
English speaking
At least 3 months post trans-radial amputation
Otherwise healthy with no neurological disorders
Must ambulate without assistance
Prosthetic limb not required for this phase of the study

If you meet the study requirements and are interested in participating, please contact Dr. Serge Roy at (508) 545-8235 or for more information.

­Nicolas Burden and colleagues at Lancaster University, United Kingdom, are setting out to explore how an individual’s thoughts and feelings about amputation might affect the amount they use a prosthetic limb. They hope that the findings from the study will help to inform services helping people recover after a limb amputation.

The team at Lancaster would like to hear from individuals who have an amputated limb, access to a prosthetic limb and are 16 years of age or above.

If you fit the description above, consider taking part in the brief online study by following
this link;

Or contact Nicolas directly at if you have any questions or to
request a paper copy of the study.

­Researchers at the University of Michigan invite individuals with upper limb loss to participate in an online research survey regarding novel prosthetic technologies. The goals of this study are to:

  • Evaluate general interest in new prosthetic technologies
  • Determine whether demographic factors (like age or level of amputation) affect level of interest in new prosthetic technologies

Your input on these matters is valuable and can help researchers in establishing design criteria for future prostheses.

You are eligible to participate if:

  • You are 18 years of age or older
  • You have an upper limb amputation at the wrist or higher

Participants will receive a gift card for completing the survey.

If you would like to participate, please go to: The survey may also be accessed at:

For more information about this study, please contact Susannah Engdahl at

The principal investigator of this study is Deanna Gates, PhD ( Dr. Gates runs the Rehabilitation Biomechanics Laboratory at the University of Michigan.

We are conducting a research study to develop new prosthesis control technology. This technology uses electrical signals recorded from muscles during muscle contraction to control an upper limb prosthesis.

The outcome of this study may someday allow upper limb amputees to control movements of a prosthesis more naturally and intuitively.


  • As a participant, you will be asked to perform low-level physical activities such as arm reaching, feeding motion, opening/closing your hand, and wrist movement.
  • The research study will be conducted at NC State University in Raleigh, NC.
  • Compensation is $25/hour with a minimum of $50/visit.
  • Participants residing far from our testing center may be eligible for travel and lodging reimbursement.


  • Between the age of 18 and 70
  • At least 1 year post-amputation
  • With amputation between the elbow and wrist
  • Free from cognitive impairment
  • Free from serious illnesses (i.e. stroke, severe heart disease, etc.)
  • Without history of serious illness (cardiac arrest, seizure, etc.)
  • Fluent in English (for consent form and appropriate communication)

For more information, please contact the
program director, Dr. He (Helen) Huang:

Neuromuscular Rehabilitation Engineering Lab
Joint Department of Biomedical Engineering

The purpose of this research study is to evaluate known risk factors of cardiovascular disease (i.e. weight, diet, exercise).

Studies have shown that people who have amputations may have an increased risk of some of these risk factors.

You may benefit from early detection of risk factors of developing cardiovascular disease. However, no benefit can be guaranteed.


  1. Over the age of 18
  2. > 3 months since most recent surgery
  3. No orthopedic injury treated during past year


Orthopedic injury treated during past year (not major limb loss)


Major limb loss resulting from trauma

Time commitment:

  • 2 visits (baseline & 5 yr follow-up)
  • Each visit ~ 90 minutes

Location of Testing:

  • WRNMMC Nutrition Research Laboratory
  • WRNMMC Amputee Care Service

If interested, please contact:

Alison Pruziner
(Principal Investigator)


  1. Over the age of 18
  2. Received unilateral, traumatic transtibial amputation

Walking Portion:

  1. Able to complete at least a 10 minute walk without upper extremity support
  2. Completed walking rehabilitation

Running Portion:

  1. Able to complete at least a 10 minute run without upper extremity support

Time Commitment:

Both portions:

4 to 5 months

  • 5 assessments at 2 hours to 2 hours

30 minutes each

  • 24 training visits at 30 minutes each

Walking portion:

2-3 months

  • 3 assessments
  • 12 training visits

Running Portion:

2-3 months

  • 3 assessments
  • 12 training visits

Location of Testing:

  • WRNMMC Amputee Care Service

The purpose of this research study is to see if a retraining program using real-time feedback improves how you walk, run and perform
other functional activities.

You may benefit from this study because the training may improve the way you walk and run. This will hopefully help increase your daily
level of function and help you avoid getting other injuries. However, no benefit can be guaranteed.

Principal Investigator:
Alison Pruziner

If interested, please contact:
Amanda Wingate

The Department of Rehabilitation at Walter Reed National Military Medical Center (WRNMMC) is currently recruiting up to 105 individuals with (and without) lower-extremity trauma or amputations to investigate how spine motion affects loads in the low back, and how these motions/loads are related to the current health of the spine and tissues in the low back.

Eligibility: Age = 18-45 years

Unilateral transtibial or transfemoral amputation, or no injuries
No upper-extremity amputation(s) above the wrist Current (or no) low back pain

Time Commitment: a single 2-hour visit

Location: Biomechanics Laboratory, America Building (19), Room B314

Possible Benefits: Results from this study could improve our understanding of why persons with lower-extremity amputation are susceptible to low back pain.

For more information, contact:
Brad Hendershot, PhD
America Building (19), Room B-311

1) Over the age of 18
2) Below-knee amputation on only one leg
3) Over a year since your amputation
4) Able to use your prosthesis, but you have difficulty doing high-level activities, such as running or jumping

Location of Testing
Walter Reed National Military Medical Center

  • Amputee Center
  • Prosthetics and Orthotics Service
  • Military and Advanced Training Center

Time Commitment
One year
First 6 months: 5 clinic visits and 2 prosthetic fittings
Second 6 months: 2 telephone calls to complete questionnaires

Purpose of Study

The purpose of the study is to learn if there are differences between a powered ankle prosthesis and the unpowered prosthesis you currently
wear. We will look at differences in how you walk in both prostheses, if one allows you to use less energy when you walk, and if one allows you to participate in and perform more activities than the other.

There is no guarantee that you will benefit from this study, however other research studies have shown that the use of a powered ankle prosthesis may decrease the stress on your un-amputated leg and may reduce the energy you require to complete daily tasks.

Principle Investigator:
Alison Pruziner

If interested, please contact:
Amanda Wingate

Caitlin Mahon

WRNMMC is conducting a s tudy to better understand how
individuals with lower limb amputation learn to walk in new


  • 18-50 years
  • Able to walk comfortably on a treadmill for 15 minutes
  • Received a unilateral lower limb amputation


  • Uninjured adult

Time Commitment: 2 hours

If interested please contact:
Erik Wolf

Version 4: 11/21/2014

Researchers at the University of Illinois at Chicago, in collaboration with practitioners at Scheck and Siress Orthotics and Prosthetics, are trying to understand how different socket suspension systems affect how much you use your prosthetic, your balance confidence and your locomotor capabilities.

Your participation would involve filling out short on-line surveys from home. The total time to complete all surveys is 15-20 minutes and you will be compensated for your time.

We are looking for participants that meet the following criteria:

  • Must be at least 18 years of age
  • Must be at least 1 year since amputation
  • Must be using current prosthetic for at least 6 months
  • Must have, or have access to an active email account
  • Must walk without the use of a cane or walker
  • Must answer yes to the following: “I can walk continuously for 6 minutes.”
  • Must not currently use a vacuum assisted socket suspension system

For further information, please contact the primary investigator, Noah Rosenblatt, PhD, at 312-996-2747.

This study is funded by the American Orthotic and Prosthetics Association

A multi-center study is underway utilizing an investigational medical device for people with post-amputation pain. If you are experiencing moderate to severe post-amputation pain not controlled by medication, we invite you to learn more.

Qualifications for study participation include:

  • One amputated lower limb
  • Frequent and recurring amputation pain
  • Willingness to undergo surgery
  • 21 years of age or older

The purpose of this clinical study is to evaluate whether electrical nerve block is a safe and effective treatment for patients with post-amputation pain. You will not be charged for any study related appointments or procedures.

For more information please contact: Neuros Medical, Inc.,,