The Amputee Coalition – the leading national organization for people with limb loss – recognizes the value of clinical research in identifying needs, evaluating care, and developing new technologies for people with limb loss.
Click here to download the policy that describes the application process through which Amputee Coalition may agree to participate in the recruitment of subjects for research.If you are a researcher and wish to submit an application for Amputee Coalition’s participation in recruitment as described in the policy, please send an e-mail notification to research@amputee-coalition.org.
Learn About Clara and Other National Trials
If you are interested in exploring a national database of clinical trials, try out the Clara Health tool or learn more about the Amputee Coalition’s partnership by scrolling down on mobile or checking the left hand navigation on a laptop.
Projects Approved for Amputee Coalition Participation
The project(s) on this page are those who have completed all the necessary documentation to assure that the research project’s human subject protocols are approved through a recognized institution’s Institutional Review Board and has provided a statement that there are no commercial conflicts of interest. This listing does not imply endorsement of the Amputee Coalition. Research projects are listed as a service to researchers and the limb loss community. The Amputee Coalition is not responsible for the conduct of the researchers. The sponsoring institution assumes responsibility for researcher conduct.
Location
San Francisco, CA
Research Objective
Patients with above knee amputations due to trauma, infection or cancer, and who have problems with or cannot use a traditional socket-based leg prosthesis are potential candidates. Implantation of this device will require two separate surgeries with a monitored rehabilitation program to follow. This is a bone anchored percutaneous titanium fixture for the rehabilitation of patients with transfemoral amputation.
To Participate, you need to be:
Have problems with or cannot use a traditional socket-based leg prosthesis are potential candidates
Compensation
None
Enrollment Open Until
November 2021
Duration
2 separate surgeries
Primary Contact
icoresinfo@ucsf.edu
415-502-4201
Link
N/A
Location
Tampa, FL
Research Objective
ADAPT-MP, an adaptive, game-based modular software solution paired with an innovative hardware solution to support basic pre-prosthetic training utilizing a portable low-cost EMG sensor, will be assessed
To Participate, you need to be:
18 – 70 years old; current myoelectric prosthesis user; have had an amputation or are missing the limb at or above the wrist and below the elbow (transradial); have enough neurological and cognitive function to operate the prosthesis well, as determined by study personnel, and operate a mobile device (phone, tablet); are free of other medical conditions that could interfere with function of the prosthesis
Compensation
$75 per visit, travel assistance may be considered for non-local participants.
Enrollment Open Until
September 2021
Duration
Total commitment is 6 weeks of at-home training with 3 on-site visits. Visits 1 and 2 (1 hour, 3 weeks apart) consist of testing, surveys, and training exercises. Visit 3 will be the last day of testing and surveys.
Primary Contact
Anita Ramrattan
Link
N/A
Location
Northwestern University, Chicago
Research Objective
The goal of this project is to better understand how upper limb loss or deficiency may affect walking balance. Participants will visit the laboratory at Northwestern University once for up to 3 hours. Your movement will be observed while you experience a safe and controlled walking disturbance.
To Participate, you need to be:
- 18-65 years old;
- upper limb loss or deficiency below the elbow on one arm;
- use of an upper limb prosthesis;
- No lower limb loss or deficiency
Compensation
$75
Enrollment Open Until
December 2021
Duration
2.5 hours
Primary Contact
Matthew J Major
matthew-major@northwestern.edu
Link
https://clinicaltrials.gov/ct2/show/NCT04274218?term=NCT04274218&draw=2&rank=1
Location
Online Survey
Research Objective
To evaluate the influence of various social media platforms and the impact of patient satisfaction and expectations in their upper limb and/or lower limb prosthetic devices.
To Participate, you need to be:
U.S. Resident, above 18 years old, any level of major limb loss
Compensation
Five people will be given the chance to win $25 each.
Enrollment Open Until
August 2021
Duration
10 minutes
Primary Contact
Caroline Leach
cleach@students.llu.edu
Link
https://qfreeaccountssjc1.az1.qualtrics.com/jfe/form/SV_4GGf6FjYiZ6kNHD
Location
Online
Research Objective
The goal of this study is to gather information pertaining to the interest in an aesthetic cover by users of transtibial prosthesis. This cover is meant to be primarily for aesthetic purposes so that users can have a product that is more personal and to their liking.
To Participate, you need to be:
Transitibal amputation, over 18 years old
Compensation
None
Enrollment Open Until
May 2021
Duration
5-10 minutes
Primary Contact
Nicholas Riley
thomas.sugar@asu.edu
Link
https://docs.google.com/forms/d/e/1FAIpQLScRGtpUbPvmjBHsaA59VhugDyjIiOAH9K5Ini2JTU0Q-ItT4A/viewform
Location
Online Survey
Research Objective
Investigate differences between different populations of upper extremity amputees regarding balance confidence and fall prevention education.
To Participate, you need to be:
Upper extremity amputee
Compensation
None
Enrollment Open Until
March 2021
Duration
5-10 minutes
Primary Contact
kvanantw@emich.edu
Location
Online
Research Objective
This study seeks approximately 15 volunteers with at least one limb amputation to investigate the frequency and severity of different types of pain related to amputation. In addition, the study looks at the relationship between pain and several factors including time of day, weather, use of medication and prosthetic devices. We are especially interested in the ways that people seek relief from their pain.
Compensation
You will receive $100 for completing the study.
Enrollment Open Until
January 2022
Duration
Participation is completely online and lasts approximately 8 days. On the first day, you will sign up online and complete initial questionnaires that take approximately 30 minutes to 1 hour.
After the initial questionnaires, this study requires a total of ~10 minutes per day for 7 days. You will complete short surveys about your current pain levels multiple times per day.
Primary Contact
If you have questions or would like to speak to a study representative, please call the Rehabilitation Neuroscience lab at 573-882-4572 or email us at freylab@missouri.edu.
Link
For more information or to enroll, please visit this link: https://showmeportal.missouri.edu/redcap/surveys/?s=9MWT7E74HD
*If you receive a message that enrollment is full when you click on the study link but you wish to be notified when enrollment opens again, please contact us and we will provide more information.
Location
Online
Research Objective
The goal is to better understand upper limb prosthesis user views on perceived function, pain, comfort, and satisfaction for various types of prosthetic devices. Responses to the survey can be used to advise the review of new prosthetic devices, which may provide the prosthesis user community with more meaningful and functional prosthetic technology advancements. The survey results will also be used to identify devices and treatment protocols that will result in increased functionality, comfort, and long-term device use.
To Participate, you need to be:
18 years or older
Have upper limb loss at any level
Currently using a prosthesis
Compensation
Confirmed completion of survey enters you in a lottery to win $20 gift card
Enrollment Open Until
December 2022
Duration
15-20 minutes
Primary Contact
Kimberly Konston
Kimberly.kontson@fda.hhs.gov
Link
Send an email to request more information and enroll
Location
Online
Research Objective
To investigate the psychological effects of amputation and whether amputation causes emotional distress regardless of the cause of amputation
To Participate, you need to be:
Have had an amputation
Compensation
none
Enrollment Open Until
March 2021
Duration
5 minutes
Primary Contact
Fazia Farhad
ffarha1@emich.edu
Location
Phone interviews
Research Objective
The goal is to understand the experiences of prosthesis dexterity, control, and sensory feedback to understand the needs and priorities of upper limb prosthesis users.
To Participate, you need to be:
18 years or older
Speak English
Be a unilateral acquired trans-radial or trans-humeral amputee
Had an amputation at least 6 months ago
Currently using a prosthesis
Compensation
$20 for each one hour interview or survey in the form of a Visa Gift Card (up to 2 sessions per person).
Enrollment Open Until
Mar 2022
Duration
2: 45-60 minute interviews OR 1 hour of survey questions
Primary Contact
Alesia Lambert
216-791-3800 x63801
Link
N/A
Location
Chicago, IL
Research Objective
This study is evaluating an intervention that targets balance confidence by integrating physical therapy (PT) exercises that address the domains of balance and functional gait, with cognitive behavioral therapy (CBT) strategies targeting self-efficacy and activity avoidance, in order to reduce avoidance behaviors related to low balance confidence that limit community participation.
To Participate, you need to be:
Be 18 years of age or older
Have a below knee amputation on one side only
Have used a definitive prosthesis for at least 6 months
Be able to stand with minimum assistance for at least 2 minutes”
Compensation
Reimbursement varies depending on group assignment. Completion of all activities in the control groups results in $270 reimbursement. Completion of all activities in the intervention group result in $620 compensation.
Enrollment Open Until
Oct 2021
Duration
24 weeks
Primary Contact
McKenzie Bourque
mckenzie.bourque@my.rfums.org
224-570-7119
Location
Online
Research Objective
To evaluate the validity of existing Fear of Falling activity avoidance scales in persons with lower limb amputation.
To Participate, you need to be:
Be 18 years of age or older
Have a lower limb amputation that occurred at least six months ago
Have access to an active email account to receive compensation
Enrollment Open Until
May 2022
Compensation
$15 gift card
Duration
30-50, minutes
Primary Contact
Noah Rosenblatt
noah.rosenblatt@roslaindfrankin.edu
847-578-8425
Location
Online, follow-up interview
Research Objective
To understand what kinds of feedback/information individuals who use lower-limb prostheses think would be useful to receive while walking to improve their mobility.
To Participate, you need to be:
Over 18 years of age, and currently using a lower limb prosthetic device.
Compensation
None
Enrollment Open Until
March 2021
Duration
Survey: 10 minutes
Potential follow-up interview: 30 minutes Total: between 10 and 40 minute
Primary Contact
Lauren Smail
smaillc@mcmaster.ca
412-726-7950
Location
Online
Research Objective
Investigate the extent COVID-19 related restrictions have impacted mental health, physical activity, an access to care among individuals with amputation.
To Participate, you need to be:
All individuals with either an upper or lower extremity amputation who use a prosthesis and have been impacted by COVID-19 restrictions.
Compensation
None
Enrollment Open Until
May 2021
Duration
20 minutes
Primary Contact
Kyle Leister
krleiste@syr.edu
412-726-7950
Location
Online (two surveys)
Research Objective
To assess the psychometric properties (validity and reliability) of surveys to measure mobility and fall-related health in lower limb prosthesis users.
To Participate, you need to be:
18+ years of age; able to read, write, and understand English; major lower limb amputation; use of a prosthesis for 3+ months, mobility challenges on curbs/stairs
Compensation
$40 for two surveys
Enrollment Open Until
March 2021
Duration
1 hour total
Primary Contact
Brian Hafner
bhafner@uw.edu
Location
25 Clinical Sites in US
Research Objective
The purpose of this clinical trial is to evaluate whether electrical nerve block via the Altius System is a safe and effective treatment for patients with post-amputation pain (phantom/stump).
To Participate, you need to be:
One amputated lower limb; Frequent and recurring pain (phantom or stump) which resulted from amputation
Compensation
No cost for study participation.
Reimbursement for your time and expenses.
Transportation for all visits provided at no cost if needed
Enrollment Open Until
Open unitl all 180 Subjects are successfully enrolled.
Duration
One Year, optional long term follow-up
Primary Contact
Neuros Medical
(888) 255-3830
Link
N/A
Location
VA New York Harbor Healthcare System, Manhattan, NY
Research Objective
The purpose of the study is to learn if there are differences between a powered ankle prosthesis and the unpowered prosthesis you currently wear.
To Participate, you need to be:
Over the age of 18; below-knee amputation on only one leg; over a year since your amputation; able to use your prosthesis and mainly use your prosthesis for community ambulation or household use
Compensation
N/A
Enrollment Open Until
N/A
Duration
6 months: 5 clinic visits and 2 prosthetic fittings
Primary Contact
Michael Hyre
michael.hyre@va.gov
Link
N/A
Location
Raleigh, NC
Research Objective
Research study to develop new prosthesis control technology. This technology uses electrical signals recorded from muscles during muscle contraction to control an upper limb prosthesis.
To Participate, you need to be:
Between the age of 18 and 70; at least 1 year post-amputation; with amputation between elbow and wrist; free from cognitive impairment; free from serious illness; without history of serious illness; fluent in English
Compensation
$50/hour with minimum of $50/visit
Enrollment Open Until
N/A
Duration
N/A
Primary Contact
He (Helen) Huang
919-515-5218
hhuang11@ncsu.edu
Link
N/A
Location
Newark, DE
Research Objective
A study assessing changes in light touch sensation, vibration detection, and pain-pressure threshold in adults with lower-limb loss with and without chronic pain compared to healthy adults without lower-limb loss. If eligible, you would be asked to answer questions about pain and function, participate in a clinical evaluation of your balance and sensation, and wear an activity monitor for 7 days.
To Participate, you need to be:
Ages 18 years and older; have a transtibial (below-knee) amputation; use a prosthesis at least 8 hours per day
Compensation
$50 for Part I, plus an additional $40 for participating in the optional Part II
Enrollment Open Until
75 minutes for Part I, additional 45 minutes for Part II, which is optional
Duration
6 Months
Primary Contact
Delaware Limb Loss Studies Lab
ebeish@udel.edu
302-831-7142
Location
Baltimore, MD
Research Objective
We hope to help with problems like skin break-down in our patients with amputations and prosthetics.
To Participate, you need to be:
Be age 18 or older; Below the knee amputation; Willing to come in for multiple visits for as few as 6 months
Compensation
Up to $500
Enrollment Open Until
December 2021
Duration
6 Months
Primary Contact
Rehabilitation Neuroscience Lab
ctrep@jhmi.edu
410-502-SKIN
Link
N/A
Location
At your home (not change in routine necessary) and online
Research Objective
Investigate how individuals use their prosthesis in everyday life by wearing motion monitors.
To Participate, you need to be:
Use at least one upper extremity prosthetic device (of any kind); are willing to wear motion monitors for 72 hours; older than 18
Compensation
“Compensation is provided for your time”
Enrollment Open Until
October 2021
Duration
72 hours
Primary Contact
Rehabilitation Neuroscience Lab
freylab@missouri.edu
573-882-4572
Link
N/A
Location
Online
Research Objective
Seeking volunteers to participate in a survey that aims to document the differences in experience with amputation between men and women.
To Participate, you need to be:
Age 18 and older; Upper and/or lower limb loss (at the wrist/ankle or higher); At least one-year post amputation
Compensation
None
Enrollment Open Until
N/A
Duration
N/A
Primary Contact
Roxanne Disla
roxanne.disla@va.gov
Link
Survey link
Location
Online
Research Objective
Understanding how physical therapy, telehealth, and physical activity may have been impacted during COVID.
To Participate, you need to be:
18 or older, lower limb amputation
Compensation
None
Enrollment Open Until
N/A
Duration
10 minutes
Primary Contact
Daniel Lee
daniel.lee29@tour.edu
Link
Survey link